I was reading on the forums the possibility of joining mid-game. That could be an interesting handicap for friends who want to play together but not get demolished by their really good friend. Have players join up to X minutes later into the game when it starts?
We will likely see at least a TA style 'start game' handicap. The starting resources of each player and/or AI will be malleable. Perhaps someone will mod in a sliding scale of starting resource increase vs time since game start to try to encourage pop ins. As to a start delay as a means of handicap, I'm not sure that will work out as well as you think. If we both start at equal resources and you get even a one minute head start...thats a much larger handicap than you think it is (imho).